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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2B6 and Efavirenz-Containing Antiretroviral Therapy

Zeruesenay Desta, Roseann S Gammal, Li Gong, Michelle Whirl-Carrillo, Aditya H Gaur, Chonlaphat Sukasem, Jennifer Hockings, Alan Myers, Marelize Swart, Rachel F Tyndale, Collen Masimirembwa, Otito F Iwuchukwu, etc.

Clin Pharmacol Ther. 2019 Oct;106(4):726-733.

PMID: 31006110

Abstract:

The HIV type-1 nonnucleoside reverse transcriptase inhibitor, efavirenz, is widely used to treat HIV type-1 infection. Efavirenz is predominantly metabolized into inactive metabolites by cytochrome P450 (CYP)2B6, and patients with certain CYP2B6 genetic variants may be at increased risk for adverse effects, particularly central nervous system toxicity and treatment discontinuation. We summarize the evidence from the literature and provide therapeutic recommendations for efavirenz prescribing based on CYP2B6 genotypes.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP154598524 Efavirenz Efavirenz 154598-52-4 Price
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