Home
Resources
Publications
CO 2 to Terpenes: Autotrophic and Electroautotrophic α-Humulene Production with Cupriavidus necator

CO 2 to Terpenes: Autotrophic and Electroautotrophic α-Humulene Production with Cupriavidus necator

Thomas Krieg, Anne Sydow, Sonja Faust, Ina Huth, Dirk Holtmann

Angew Chem Int Ed Engl. 2018 Feb 12;57(7):1879-1882.

PMID: 29232490

Abstract:

We show that CO2 can be converted by an engineered "Knallgas" bacterium (Cupriavidus necator) into the terpene α-humulene. Heterologous expression of the mevalonate pathway and α-humulene synthase resulted in the production of approximately 10 mg α-humulene per gram cell dry mass (CDW) under heterotrophic conditions. This first example of chemolithoautotrophic production of a terpene from carbon dioxide, hydrogen, and oxygen is a promising starting point for the production of different high-value terpene compounds from abundant and simple raw materials. Furthermore, the production system was used to produce 17 mg α-humulene per gram CDW from CO2 and electrical energy in microbial electrosynthesis (MES) mode. Given that the system can convert CO2 by using electrical energy from solar energy, it opens a new route to artificial photosynthetic systems.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP6753986	α-Humulene		6753-98-6	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: