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β-Cryptoxanthin Induces UCP-1 Expression via a RAR Pathway in Adipose Tissue

Hideyuki Hara, Haruya Takahashi, Shinsuke Mohri, Hiroki Murakami, Satoko Kawarasaki, Mari Iwase, Nobuyuki Takahashi, Minoru Sugiura, Tsuyoshi Goto, Teruo Kawada

J Agric Food Chem. 2019 Sep 25;67(38):10595-10603.

PMID: 31475817

Abstract:

While β-cryptoxanthin is hypothesized to have a preventive effect on lifestyle-related diseases, its underlying mechanisms are unknown. We investigated the effect of β-cryptoxanthin on energy metabolism in adipose tissues and its underlying mechanism. C57BL/6J mice were fed a high-fat diet (60% kcal fat) containing 0 or 0.05% β-cryptoxanthin for 12 weeks. β-cryptoxanthin treatment was found to reduce body fat gain and plasma glucose level, while increasing energy expenditure. The expression of uncoupling protein (UCP) 1 was elevated in adipose tissues in the treatment group. Furthermore, the in vivo assays showed that the Ucp1 mRNA expression was higher in the β-cryptoxanthin treatment group, an effect that disappeared upon cotreatment with a retinoic acid receptor (RAR) antagonist. In conclusion, we report that β-cryptoxanthin reduces body fat and body weight gain and that β-cryptoxanthin increases the expression of UCP1 via the RAR pathway.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP472708 β-Cryptoxanthin β-Cryptoxanthin 472-70-8 Price
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