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Does Daily Folic Acid Supplementation Reduce Methotrexate Efficacy?

Does Daily Folic Acid Supplementation Reduce Methotrexate Efficacy?

A Cline, J L Jorizzo

Dermatol Online J. 2017 Nov 15;23(11):13030/qt4hf5v2vk.

PMID: 29447631

Abstract:

Methotrexate is a mainstay treatment for autoimmune and inflammatory conditions in the field of Dermatology. However, in some patients, its use is associated with significant side effects and toxicity. Folate supplementation with either folic acid or folinic acid often mitigates side effects and reduces the incidence of systemic toxicity related to methotrexate. Although the value of methotrexate is clear, debate remains about folate supplementation. There is little agreement about the proper dosing or frequency of folate supplementation as many believe that daily folate supplementation can reduce methotrexate efficacy. Although daily use of folic acid does not appear to affect methotrexate efficacy, dosing of folinic acid close to methotrexate administration may hinder methotrexate efficacy. Therefore, folic acid should be used daily with methotrexate to ameliorate side effects, whereas folinic acid should only be used for methotrexate toxicity.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP59052-B	Methotrexate		59-05-2	Price

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