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Drug Repurposing of Metabolic Agents in Malignant Glioma

Corinna Seliger, Peter Hau

Int J Mol Sci. 2018 Sep 14;19(9):2768.

PMID: 30223473

Abstract:

Gliomas are highly invasive brain tumors with short patient survival. One major pathogenic factor is aberrant tumor metabolism, which may be targeted with different specific and unspecific agents. Drug repurposing is of increasing interest in glioma research. Drugs interfering with the patient's metabolism may also influence glioma metabolism. In this review, we outline definitions and methods for drug repurposing. Furthermore, we give insights into important candidates for a metabolic drug repurposing, namely metformin, statins, non-steroidal anti-inflammatory drugs, disulfiram and lonidamine. Advantages and pitfalls of drug repurposing will finally be discussed.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP50264692 Lonidamine Lonidamine 50264-69-2 Price
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