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[Effect of Aurora Inhibitor VX-680 on Proliferation and Apoptosis of CML Cells]

[Effect of Aurora Inhibitor VX-680 on Proliferation and Apoptosis of CML Cells]

Yue Yin, Hui-Yan Sun, Xiao-Lin Li, Feng-Jun Xiao, Li-Sheng Wang

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2014 Dec;22(6):1540-4.

PMID: 25543471

Abstract:

This study was aimed to explore the effect of VX-680, an aurora inhibitor, on proliferation and apoptosis of K562, KCL22 cell lines and CD34⁺ cells from chronic myeloid leukemia (CML) patients in vitro. The proliferation of K562 and KCL22 cell was detected by CCK-8 method. Apoptosis of cells was detected by Annexin V-PI labeling and flow cytometry. The colony forming ability of bone marrow CD34⁺ cells derived from CML patients and donors was determined by the colony forming test. The results showed that the treatment of K562, KCL22 and CML CD34⁺ cells with VX-680 of 20-100 nmol/L for 3 days could obviously inhibit the cell proliferation in a concentration-dependent manner (P < 0.01). VX-680 treatment significantly induced apoptosis of K562 and KCL22 cells. Compared to bone marrow CD34⁺ cells derived from the healthy donors, the colony forming ability of CML CD34⁺ cells derived from bone marrow of CML patients was remarkably reduced (P < 0.01). It is concluded that VX-680, an aurora inhibitor, can inhibit the proliferation and induce apoptosis of CML cells in vitro.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP639089546	VX-680		639089-54-6	Price

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