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Efficient Synthesis of ESI-09, A Novel Non-cyclic Nucleotide EPAC Antagonist

Haijun Chen, Chunyong Ding, Christopher Wild, Huiling Liu, Tianzhi Wang, Mark A White, Xiaodong Cheng, Jia Zhou

Tetrahedron Lett. 2013 Mar 20;54(12):1546-1549.

PMID: 23459418

Abstract:

A concise and efficient synthetic approach to producing a novel non-cyclic nucleotide EPAC antagonist ESI-09 and its new analogs is reported. Key features of the synthesis include a mild and reliable one-pot procedure for an isoxazole synthon, as well as a modified one-pot protocol for the cyanomethyl ketone key intermediate. The synthesis requires inexpensive starting materials and only three linear steps for the completion in a total yield of 53%.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP263707160 ESI-09 ESI-09 263707-16-0 Price
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