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ERK Inhibition With PD184161 Mitigates Brain Damage in a Mouse Model of Stroke

Amadeus Gladbach, Janet van Eersel, Mian Bi, Yazi D Ke, Lars M Ittner

J Neural Transm (Vienna). 2014 May;121(5):543-7.

PMID: 24337667

Abstract:

Ischemic stroke is a leading cause of death. It has previously been shown that blocking activation of extracellular signal-regulated kinase (ERK) with the MEK inhibitor U0126 mitigates brain damage in rodent models of ischemic stroke. Here we show that the newer MEK inhibitor PD184161 reduces cell death and altered gene expression in cultured neurons and mice undergoing excitotoxicity, and has similar protective effects in a mouse model of stroke. This further supports ERK inhibition as a potential treatment for stroke.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP212631679 PD-184161 PD-184161 212631-67-9 Price
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