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Evaluation of Two Inhibitors of Invasion: LY311727 [3-(3-acetamide-1-benzyl-2-ethyl-indolyl-5-oxy)propane Phosphonic Acid] and AEBSF [4-(2-aminoethyl)-benzenesulphonyl Fluoride] in Acute Murine Toxoplasmosis

Evaluation of Two Inhibitors of Invasion: LY311727 [3-(3-acetamide-1-benzyl-2-ethyl-indolyl-5-oxy)propane Phosphonic Acid] and AEBSF [4-(2-aminoethyl)-benzenesulphonyl Fluoride] in Acute Murine Toxoplasmosis

Rafael Buitrago-Rey, Jorge Olarte, Jorge Enrique Gomez-Marin

J Antimicrob Chemother. 2002 May;49(5):871-4.

PMID: 12003987

Abstract:

We examined the effect of an inhibitor of secretory phospholipase A2 type II (LY311727) and of a specific inhibitor of serine proteases (AEBSF) in a murine model of acute toxoplasmosis. LY311727 did not afford any significant protection and produced earlier mortality compared with untreated mice at a dose of 100 mg/kg. In contrast, AEBSF demonstrated a significant increase in length of survival, and this effect was enhanced when AEBSF was administered with non-protective doses of pyrimethamine.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP164083845	LY311727		164083-84-5	Price

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