Home
Resources
Publications
Fenobam Promoted the Neuroprotective Effect of PEP-1-FK506BP Following Oxidative Stress by Increasing Its Transduction Efficiency

Fenobam Promoted the Neuroprotective Effect of PEP-1-FK506BP Following Oxidative Stress by Increasing Its Transduction Efficiency

Eun Hee Ahn, Dae Won Kim, Min Jea Shin, Hyo Sang Jo, Seon Ae Eom, Duk-Soo Kim, Eun Young Park, Jong Hoon Park, Sung-Woo Cho, Jinseu Park, Won Sik Eum, Ora Son, Hyun Sook Hwang, Soo Young Choi

BMB Rep. 2013 Nov;46(11):561-6.

PMID: 24152913

Abstract:

We examined the ways in which fenobam could promote not only the transduction of PEP-1-FK506BP into cells and tissues but also the neuroprotective effect of PEP-1-FK506BP against ischemic damage. Fenobam strongly enhanced the protective effect of PEP-1-FK506BP against H2O2-induced toxicity and DNA fragmentation in C6 cells. In addition, combinational treatment of fenobam with PEP-1-FK506BP significantly inhibited the activation of Akt and MAPK induced by H2O2, compared to treatment with PEP-1-FK506BP alone. Interestingly, our results showed that fenobam significantly increased the transduction of PEP-1-FK506BP into both C6 cells and the hippocampus of gerbil brains. Subsequently, a transient ischemic gerbil model study demonstrated that fenobam pretreatment led to the increased neuroprotection of PEP-1-FK506BP in the CA1 region of the hippocampus. Therefore, these results suggest that fenobam can be a useful agent to enhance the transduction of therapeutic PEP-1-fusion proteins into cells and tissues, thereby promoting their neuroprotective effects.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP57653266	Fenobam		57653-26-6	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: