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Fine-tuning S1P Therapeutics

Hideru Obinata, Timothy Hla

Chem Biol. 2012 Sep 21;19(9):1080-2.

PMID: 22999874

Abstract:

Sphingosine 1-phosphate receptor-1 (S1P(1)), a novel therapeutic target for multiple sclerosis, regulates lymphocyte trafficking, heart rate, and vascular function. The discovery of NIBR-0213, a competitive antagonist for S1P(1) that inhibits autoimmune inflammation while sparing bradycardia (Quancard et al., in this issue of Chemistry & Biology), suggests that fine-tuning of S1P(1) modulators may lead to novel immune modulators with better efficacy to adverse events ratio.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1233332143 NIBR-0213 NIBR-0213 1233332-14-3 Price
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