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Formation of Nanoparticles by Cooperative Inclusion Between (S)-camptothecin-modified Dextrans and β-cyclodextrin Polymers

Formation of Nanoparticles by Cooperative Inclusion Between (S)-camptothecin-modified Dextrans and β-cyclodextrin Polymers

Thorbjørn Terndrup Nielsen, Catherine Amiel, Laurent Duroux, Kim Lambertsen Larsen, Lars Wagner Städe, Reinhard Wimmer, Véronique Wintgens

Beilstein J Org Chem. 2015 Jan 21;11:147-54.

PMID: 25670998

Abstract:

Novel (S)-camptothecin-dextran polymers were obtained by "click" grafting of azide-modified (S)-camptothecin and alkyne-modified dextrans. Two series based on 10 kDa and 70 kDa dextrans were prepared with a degree of substitution of (S)-camptothecin between 3.1 and 10.2%. The binding properties with β-cyclodextrin and β-cyclodextrin polymers were measured by isothermal titration calorimetry and fluorescence spectroscopy, showing no binding with β-cyclodextrin but high binding with β-cyclodextrin polymers. In aqueous solution nanoparticles were formed from association between the (S)-camptothecin-dextran polymers and the β-cyclodextrin polymers.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP7689034-B	(S)-(+)-Camptothecin		7689-03-4	Price

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