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Heterologous Reconstitution of Ikarugamycin Biosynthesis in E. Coli

Heterologous Reconstitution of Ikarugamycin Biosynthesis in E. Coli

Janine Antosch, Françoise Schaefers, Tobias A M Gulder

Angew Chem Int Ed Engl. 2014 Mar 10;53(11):3011-4.

PMID: 24519911

Abstract:

Polycyclic tetramate macrolactams (PTMs) are a family of biomedically promising natural products with challenging molecular frameworks. Despite these interesting properties, so far only relatively little is known about the biosynthetic origin of PTMs, in particular concerning the mechanism by which their ring systems are formed. Herein we present the first insights into these processes by using the biosynthesis of ikarugamycin as an example. This has been facilitated by the first heterologous expression of a PTM biosynthetic gene cluster in Escherichia coli. With this approach it will not only become possible to mechanistically investigate already known PTM biosynthetic pathways in more detail in the future, but also to interrogate cryptic PTM biosynthetic pathways chemically and biochemically.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP36531789	Ikarugamycin		36531-78-9	Price

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