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Immunomodulatory Properties of Soluble Recombinant Human CD58 (LFA-3) Molecules

M Albert-Wolf, S C Meuer, R Wallich

Dev Biol Stand. 1992;77:87-92.

PMID: 1385237

Abstract:

The interaction between the E-rosette receptor (CD2) expressed on the cell surface of T lymphocytes and its natural ligand CD58 (LFA-3), a broadly distributed cell surface molecule, represents a potential target for immune modulation. To explore this possibility, we have expressed a soluble recombinant form of human CD58 which exerts potent biological effects in that it acts as a competitive inhibitor for cell surface CD58 in its binding to CD2 positive lymphocytes. Thus, recombinant CD58 blocks NK-mediated cytotoxicity, the mixed lymphocyte reaction, and the T lymphocyte adhesion to CD58 positive cells. In contrast, recombinant CD58 synergized with mitogenic CD2R monoclonal antibodies (anti-T11(2/3) or 9.1) in T cell triggering.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
IAR42413191 CD58/LFA-3 human CD58/LFA-3 human Price
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