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Immunostimulatory Cancer Chemotherapy Using Local ingenol-3-angelate and Synergy With Immunotherapies

Immunostimulatory Cancer Chemotherapy Using Local ingenol-3-angelate and Synergy With Immunotherapies

Thuy T T Le, Joy Gardner, Diem Hoang-Le, Chris W Schmidt, Kelli P MacDonald, Eleanore Lambley, Wayne A Schroder, Steven M Ogbourne, Andreas Suhrbier

Vaccine. 2009 May 18;27(23):3053-62.

PMID: 19428919

Abstract:

Ingenol-3-angelate is a new local chemotherapeutic agent in clinical trails that induces primary necrosis of tumour cells and transient local inflammation. Here we show that cure of subcutaneous tumours with ingenol-3-angelate (PEP005) resulted in the generation of anti-cancer CD8 T cells that could regress metastases. Furthermore, PEP005-mediated cure synergized with several CD8 T cell-based immunotherapies to regress further distant metastases. PEP005 was shown to have adjuvant properties, being able to upregulate CD80 and CD86 expression on dendritic cells in vivo, and to promote CD8 T cell induction when co-delivered with a protein antigen. PEP005 thus emerges as a unique local chemotherapeutic immunostimulatory debulking agent that could be used in conjunction with immunotherapies to promote regression of metastases.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP75567372	Ingenol-3-angelate		75567-37-2	Price

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