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Impact of Antibacterial Drugs on Human Serum paraoxonase-1 (hPON1) Activity: An in Vitro Study

Impact of Antibacterial Drugs on Human Serum paraoxonase-1 (hPON1) Activity: An in Vitro Study

Hakan Söyüt, Elif Duygu Kaya, Sükrü Beydemir

Asian Pac J Trop Biomed. 2014 Aug;4(8):603-9.

PMID: 25183328

Abstract:

Objective:
To investigate the in vitro effects of the antibacterial drugs, meropenem trihydrate, piperacillin sodium, and cefoperazone sodium, on the activity of human serum paraoxonase (hPON1).
Methods:
hPON1 was purified from human serum using simple chromatographic methods, including DEAE-Sephadex anion exchange and Sephadex G-200 gel filtration chromatography.
Results:
The three antibacterial drugs decreased in vitro hPON1 activity. Inhibition mechanisms meropenem trihydrate was noncompetitive while piperacillin sodium and cefoperazone sodium were competitive.
Conclusions:
Our results showed that antibacterial drugs significantly inhibit hPON1 activity, both in vitro, with rank order meropenem trihydrate piperacillin sodium cefoperazone sodium in vitro.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP119478567-A	Meropenem trihydrate		119478-56-7	Price

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