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Improvement of Contextual Memory by S 24795 in Aged Mice: Comparison With Memantine

Improvement of Contextual Memory by S 24795 in Aged Mice: Comparison With Memantine

Daniel Beracochea, Aurelie Boucard, Caryn Trocme-Thibierge, Philippe Morain

Psychopharmacology (Berl). 2008 Mar;196(4):555-64.

PMID: 18034231

Abstract:

Results:
In comparison with 5-month-old mice, 18- to 19-month-old mice exhibited a severe and specific memory impairment in a contextual serial discrimination (CSD) task involving the learning and remembering of two successive spatial discriminations carried out on two distinct floors. This impairment was specific, as spatial memory, simultaneously tested on a simple discrimination (SD) task, was not affected in these aged mice. This deficit was completely reversed by 9-day per os administration of S 24795, a partial agonist of alpha 7 nicotinic receptors, at either 0.3 or 1.0 mg/kg. Memantine, an NMDA receptor antagonist, also had a memory-enhancing effect at a dose of 3.0 mg/kg, but not at 0.3 mg/kg.
Conclusions:
The memory-enhancing effect of S 24795 was due to a strong enhancement of contextual memory as indicated by a decrease in interference rate, whereas memantine enhanced spatial/semantic memory. S 24795 was more effective than memantine and also appears to be more specific to flexible forms of memory, one of the first cognitive domains (i.e. episodic memory) affected in Alzheimer's disease.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP304679752	S 24795		304679-75-2	Price

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