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Inhibiting Extracellular Vesicles Formation and Release: A Review of EV Inhibitors

Inhibiting Extracellular Vesicles Formation and Release: A Review of EV Inhibitors

Mariadelva Catalano, Lorraine O'Driscoll

J Extracell Vesicles. 2019 Dec 19;9(1):1703244.

PMID: 32002167

Abstract:

It is now becoming well established that vesicles are released from a broad range of cell types and are involved in cell-to-cell communication, both in physiological and pathological conditions. Once outside the cell, these vesicles are termed extracellular vesicles (EVs). The cellular origin (cell type), subcellular origin (through the endosomal pathway or pinched from the cell membrane) and content (what proteins, glycoproteins, lipids, nucleic acids, metabolites) are transported by the EVs, and their size, all seem to be contributing factors to their overall heterogeneity. Efforts are being invested into attempting to block the release of subpopulations of EVs or, indeed, all EVs. Some such studies are focussed on investigating EV inhibitors as research tools; others are interested in the longerterm potential of using such inhibitors in pathological conditions such as cancer. This review, intended to be of relevance to both researchers already well established in the EV field and newcomers to this field, provides an outline of the compounds that have been most extensively studied for this purpose, their proposed mechanisms of actions and the findings of these studies.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP117591205-A	Calpeptin		117591-20-5	Price
AP6823694	GW4869		6823-69-4	Price

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