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Inhibition of caspase-1 Induces Cell Death in Pancreatic Carcinoma Cells and Potentially Modulates Expression Levels of bcl-2 Family Proteins

S Schlosser, F Gansauge, M Ramadani, H G Beger, S Gansauge

FEBS Lett. 2001 Feb 23;491(1-2):104-8.

PMID: 11226429

Abstract:

Caspase-1 (interleukin-1beta-converting enzyme) is reported to play an important role in the regulation of apoptosis. We investigated the inhibition of caspase-1 by the cell permeable caspase-1 inhibitor Ac-AAVALLPAVLLALLAP-YVAD.CHO in pancreatic carcinoma cells. Inhibition of caspase-1 induced a non-apoptotic/"necrotic-like" cell death in AsPC-1, BxPC-3, MiaPaCa-2 and Panc-1 cells. Expression levels of bcl-2 and bax were up-regulated in caspase-1 inhibitor-treated cells while that of bcl-x(L) remained unaltered. Our observations support our previous findings that caspase-1 is potentially involved in anti-apoptotic processes in pancreatic carcinoma.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
IAR42415323 Caspase-1 Inhibitor I, Cell-Permeable Caspase-1 Inhibitor I, Cell-Permeable Price
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