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Inhibition of GPR40 Protects MIN6 β Cells From Palmitate-Induced ER Stress and Apoptosis

Inhibition of GPR40 Protects MIN6 β Cells From Palmitate-Induced ER Stress and Apoptosis

Jinwei Wu, Peng Sun, Xiaodong Zhang, Hong Liu, Hualiang Jiang, Weiliang Zhu, Heyao Wang

J Cell Biochem. 2012 Apr;113(4):1152-8.

PMID: 22275065

Abstract:

Chronic exposure to elevated concentration of free fatty acids (FFA) has been verified to induce endoplasmic reticulum (ER) stress, which leads to pancreatic β-cell apoptosis. As one of the medium and long chain FFA receptors, GPR40 is highly expressed in pancreatic β cells, mediates both acute and chronic effects of FFA on β-cell function, but the role of GPR40 in FFA-induced β-cell apoptosis remains unclear. In this study, we investigated the possible effects of GPR40 in palmitate-induced MIN6 β-cell apoptosis, and found that DC260126, a novel small molecular antagonist of GPR40, could protect MIN6 β cells from palmitate-induced ER stress and apoptosis. Similar results were observed in GPR40-deficient MIN6 cells, indicating that palmitate-induced β-cell apoptosis is at least partially dependent on ER stress pathway via GRP40.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP346692044	DC260126		346692-04-4	Price

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