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Inhibition of sPLA₂-IIA Prevents LPS-induced Neuroinflammation by Suppressing ERK1/2-cPLA₂α Pathway in Mice Cerebral Cortex

Inhibition of sPLA₂-IIA Prevents LPS-induced Neuroinflammation by Suppressing ERK1/2-cPLA₂α Pathway in Mice Cerebral Cortex

Yanxiao Xiang, Lin Chen, Huiqing Liu, Xiaoqian Liu, Xinbing Wei, Baozhu Sun, Tian Wang, Xiumei Zhang

PLoS One. 2013 Oct 9;8(10):e77909.

PMID: 24130900

Abstract:

Neuroinflammation is involved in various central nervous system (CNS) disorders, including brain infections, ischemia, trauma, stroke, and degenerative CNS diseases. In the CNS inflammation, secretory phospholipase A₂-IIA (sPLA₂-IIA) acts as a mediator, resulting in the generation of the precursors of pro-inflammatory lipid mediators, such as prostaglandins (PGs) and leukotrienes (LTs). However, the role of sPLA₂-IIA in neuroinflammation is more complicated and remains unclear yet. In the present study, we investigated the effect of sPLA₂-IIA inhibition by specific inhibitor SC-215 on the inflammation in LPS-induced mice cerebral cortex and primary astrocytes. Our results showed that the inhibition of sPLA₂-IIA alleviated the release of PGE₂ by suppressing the activation of ERK1/2, cPLA₂α, COX-2 and mPGES-1. These findings demonstrated that sPLA₂-IIA showed the potential to regulate the neuroinflammation in vivo and in vitro, indicating that sPLA₂-IIA might be a novel target for the treatment of acute neuroinflammation.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4247119	sPLA₂-IIA Inhibitor I			Price

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