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Iridium-catalyzed Enantioselective Allyl-Alkene Coupling

James Y Hamilton, David Sarlah, Erick M Carreira

J Am Chem Soc. 2014 Feb 26;136(8):3006-9.

PMID: 24521052

Abstract:

The direct Ir-catalyzed cross-coupling between branched, racemic allylic alcohols and simple olefins is described. This transformation is catalyzed by an Ir-(P,olefin) complex and proceeds with high site selectivity and excellent enantioselectivity. The method allows rapid access to various 1,5-dienes or trienes and was used in the catalytic asymmetric synthesis of the γ-secretase modulator JNJ-40418677.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1146594877 JNJ-40418677 JNJ-40418677 1146594-87-7 Price
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