Home
Resources
Publications
Itaconic Acid Production in Microorganisms

Itaconic Acid Production in Microorganisms

Meilin Zhao, Xinyao Lu, Hong Zong, Jinyang Li, Bin Zhuge

Biotechnol Lett. 2018 Mar;40(3):455-464.

PMID: 29299715

Abstract:

Itaconic acid, 2-methylidenebutanedioic acid, is a precursor of polymers, chemicals, and fuels. Many fungi can synthesize itaconic acid; Aspergillus terreus and Ustilago maydis produce up to 85 and 53 g l-1, respectively. Other organisms, including Aspergillus niger and yeasts, have been engineered to produce itaconic acid. However, the titer of itaconic acid is low compared with the analogous major fermentation product, citric acid, for which the yield is > 200 g l-1. Here, we review two types of pathway for itaconic acid biosynthesis as well as recent advances by metabolic engineering strategies and process optimization to enhance itaconic acid productivity in native producers and heterologous hosts. We also propose further improvements to overcome existing problems.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP97654	Itaconic acid		97-65-4	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: