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Metabolism and Brain Accumulation of Tetrahydroisoquinoline (TIQ) a Possible Parkinsonism Inducing Substance, in an Animal Model of a Poor Debrisoquine Metabolizer

Metabolism and Brain Accumulation of Tetrahydroisoquinoline (TIQ) a Possible Parkinsonism Inducing Substance, in an Animal Model of a Poor Debrisoquine Metabolizer

S Ohta, O Tachikawa, Y Makino, Y Tasaki, M Hirobe

Life Sci. 1990;46(8):599-605.

PMID: 2308469

Abstract:

4-Hydroxytetrahydroisoquinoline (4OH-TIQ) was detected as a metabolite of a possible parkinsonism-inducing substance, tetrahydroisoquinoline (TIQ), in rat liver microsomes and rat urine. Urinary excretion of 4OH-TIQ was significantly reduced in female DA rat, an animal model of a poor debrisoquine metabolizer. The female DA rat also showed significantly higher brain accumulation of TIQ. These results suggest that the metabolic detoxication process is depressed and TIQ accumulation in the brain is enhanced in a poor debrisoquine metabolizer, which may be one possible explanation for poor debrisoquine metabolizers being susceptible to Parkinson's disease.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP420849225	TIQ-A		420849-22-5	Price

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