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Methodology for the Testing of Food Dyes for Genotoxic Activity: Experiments With Red 2G (C.I. 18050)

Methodology for the Testing of Food Dyes for Genotoxic Activity: Experiments With Red 2G (C.I. 18050)

R B Haveland-Smith, R D Combes, B A Bridges

Mutat Res. 1979 Aug;64(4):241-8.

PMID: 384228

Abstract:

A methodology for investigating genotoxicity of food colours using the fluctuation and DNA-repair assays with bacteria is described. In addition, a liquid repair test, developed to permit incorporation of microsomes and the quantitative estimation of cell viability, has been characterised with a number of positive control agents. Results obtained in these systems suggest that the food colour Red 2G induces repairable DNA damage and base-substitution mutation, but only in the presence of a rat-liver microsomal preparation. The significance of the data in the light of other toxicological information is discussed.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP3734676	Red 2G		3734-67-6	Price

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