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Microbial Transformation of Epothilone A by Aspergillus Niger AS 3.739

Yan-Liang Wang, He Wang, Yu-Xin Lu, Xiao-Chen Cheng, Li-Li Han, Shou-Jun Yuan, De-Xuan Yang, Qing-Lin Zhang, Chu-Tse Wu

J Asian Nat Prod Res. 2009;11(4):357-64.

PMID: 19431017

Abstract:

The microbiological transformation of epothilone A (1) by Aspergillus niger AS 3.739 afforded four main metabolites. Their structures were elucidated by (1)H, (13)C NMR and HSQC, COSY, HMBC, and NOESY spectra as trans-12,13-hydroxylated epothilone A (2), cis-12,13-hydroxylated epothilone A (3), trans-12,15-epoxidated epothilone A (4), and cis-12,15-epoxidated epothilone A (5). All four compounds were firstly found based on their stereochemistry. These new compounds displayed cytotoxicity against human breast carcinoma cells MCF-7 with IC(50) 9.88 microg/ml of 2, 2.52 microg/ml of 3, 9.88 microg/ml of 4, and 5.68 microg/ml of 5.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP152044536 (−)-Epothilone A (−)-Epothilone A 152044-53-6 Price
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