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Micromolar L-2-amino-4-phosphonobutyric Acid Selectively Inhibits Perforant Path Synapses From Lateral Entorhinal Cortex

Micromolar L-2-amino-4-phosphonobutyric Acid Selectively Inhibits Perforant Path Synapses From Lateral Entorhinal Cortex

J F Koerner, C W Cotman

Brain Res. 1981 Jul 6;216(1):192-8.

PMID: 6266585

Abstract:

Transverse slices of the rat hippocampus were used to examine the ability of phosphonate analogues of acidic amino acids to inhibit perforant path synaptic transmission. Micromolar concentrations of L-2-amino-4-phosphonobutyric acid (APB), an analogue of L-glutamic acid, inhibited transmission from the lateral entorhinal cortex. Two other less-sensitive components were detected in projections from the medial entorhinal cortex. The component from the lateral entorhinal cortex showed high stereospecificity for the L-isomer of APB and was relatively insensitive to phosphonate homologues of shorter and longer chain length.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP23052815-A	L-(+)-2-Amino-4-phosphonobutyric acid		23052-81-5	Price

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