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Neurohypophysial Vasopressin and Oxytocin as Influenced by (6R)-5,6,7,8-tetrahydro-alpha-biopterin in Euhydrated and Dehydrated Rats

J Ciosek, J W Guzek, M Orłowska-Majdak

Biol Chem Hoppe Seyler. 1992 Oct;373(10):1079-83.

PMID: 1418678

Abstract:

Experiments were performed to test a possible role of (6R)-5,6,7,8-tetrahydro-alpha-biopterin dihydrochloride (BH4) in the neurohypophysial vasopressin and oxytocin content in euhydrated and dehydrated rats. Chronic treatment with BH4, administered to not dehydrated animals, was followed by a significant decrease of neurohypophysial vasopressin, but not of neurohypophysial oxytocin. In dehydrated animals the neurohypophysial vasopressin content decreased progressively; this process was not affected significantly by BH4. In rats dehydrated and treated simultaneously with BH4 the decrease of neurohypophysial oxytocin content was distinctly less marked.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP69056388 (6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride (6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride 69056-38-8 Price
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