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New Ikarugamycin Derivatives With Antifungal and Antibacterial Properties From Streptomyces Zhaozhouensis

Rodney Lacret, Daniel Oves-Costales, Cristina Gómez, Caridad Díaz, Mercedes de la Cruz, Ignacio Pérez-Victoria, Francisca Vicente, Olga Genilloud, Fernando Reyes

Mar Drugs. 2014 Dec 29;13(1):128-40.

PMID: 25551780

Abstract:

A bioassay guided fractionation of the ethyl acetate extract from culture broths of the strain Streptomyces zhaozhouensis CA-185989 led to the isolation of three new polycyclic tetramic acid macrolactams (1-3) and four known compounds. All the new compounds were structurally related to the known Streptomyces metabolite ikarugamycin (4). Their structural elucidation was accomplished using a combination of electrospray-time of flight mass spectrometry (ESI-TOF MS) and 1D and 2D NMR analyses. Compounds 1-3 showed antifungal activity against Aspergillus fumigatus, Candida albicans and antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP36531789 Ikarugamycin Ikarugamycin 36531-78-9 Price
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