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NH125 Kills Methicillin-Resistant Staphylococcus Aureus Persisters by Lipid Bilayer Disruption

NH125 Kills Methicillin-Resistant Staphylococcus Aureus Persisters by Lipid Bilayer Disruption

Wooseong Kim, Nico Fricke, Annie L Conery, Beth Burgwyn Fuchs, Rajmohan Rajamuthiah, Elamparithi Jayamani, Petia M Vlahovska, Frederick M Ausubel, Eleftherios Mylonakis

Future Med Chem. 2016;8(3):257-69.

PMID: 26910612

Abstract:

Background:
NH125, a known WalK inhibitor kills MRSA persisters. However, its precise mode of action is still unknown.
Methods & results:
The mode of action of NH125 was investigated by comparing its spectrum of antimicrobial activity and its effects on membrane permeability and giant unilamellar vesicles (GUVs) with walrycin B, a WalR inhibitor and benzyldimethylhexadecylammonium chloride (16-BAC), a cationic surfactant. NH125 killed persister cells of a variety of Staphylococcus aureus strains. Similar to 16-BAC, NH125 killed MRSA persisters by inducing rapid membrane permeabilization and caused the rupture of GUVs, whereas walrycin B did not kill MRSA persisters or induce membrane permeabilization and did not affect GUVs.
Conclusion:
NH125 kills MRSA persisters by interacting with and disrupting membranes in a detergent-like manner.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP278603080-B	NH125		278603-08-0	Price

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