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Nonequivalent Response to Bromodomain-Targeting BET Inhibitors in Oligodendrocyte Cell Fate Decision

Cheng-Ming Chiang

Chem Biol. 2014 Jul 17;21(7):804-6.

PMID: 25036774

Abstract:

The tandem bromodomains (BD1 and BD2) of the BET family proteins BRD2, BRD3, BRD4, and BRDT are structurally conserved but not functionally equivalent. In this issue of Chemistry & Biology, Gacias and colleagues report that a BD1-specific chemical inhibitor, Olinone, enhances oligodendrocyte differentiation, contrasting the reverse process triggered by broad BD1/BD2-targeting inhibitors, highlighting distinct roles of BD1 and BD2 in cell fate decision.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
IAR4244413 Olinone Olinone Price
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