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Oversulfated Chondroitin Sulfate Interaction With Heparin-Binding Proteins: New Insights Into Adverse Reactions From Contaminated Heparins

Oversulfated Chondroitin Sulfate Interaction With Heparin-Binding Proteins: New Insights Into Adverse Reactions From Contaminated Heparins

Boyangzi Li, Jiraporn Suwan, Jeffrey G Martin, Fuming Zhang, Zhenqing Zhang, Debra Hoppensteadt, Melanie Clark, Jawed Fareed, Robert J Linhardt

Biochem Pharmacol. 2009 Aug 1;78(3):292-300.

PMID: 19389385

Abstract:

An oversulfated chondroitin sulfate (OSCS) was identified as a contaminant to pharmaceutical heparin and severe anaphylactoid reactions were ascribed to this contaminant. An examination of the biochemistry underlying both the anticoagulant activity and the toxic effects of oversulfated chondroitin sulfate was undertaken. This study demonstrates that the anticoagulant activity of this oversulfated chondroitin sulfate is primarily dependent on heparin cofactor II mediated inhibition of thrombin. Heparin and oversulfated chondroitin sulfate binding to coagulation, kinin-kallikrein and complement proteins were studied by surface plasmon resonance. While oversulfated chondroitin sulfate binds tightly to antithrombin III, unlike heparin, OSCS does not induce antithrombin III to undergo the conformational change required for its inactivation of thrombin and factor Xa. In contrast to heparin, oversulfated chondroitin sulfate tightly binds factor XIIa suggesting a biochemical mechanism for the factor XIIa-based enhancement of vasoactive bradykinin production.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
CS31041821	Heparin Sodium with Oversulfated Chondroitin Sulfate			Price
CS31042432	Oversulfated Chondroitin Sulfate			Price

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