Home
Resources
Publications
Peptides That Regulate Food Intake: Antagonism of Opioid Receptors Reduces Body Fat in Obese Rats by Decreasing Food Intake and Stimulating Lipid Utilization

Peptides That Regulate Food Intake: Antagonism of Opioid Receptors Reduces Body Fat in Obese Rats by Decreasing Food Intake and Stimulating Lipid Utilization

Michael A Statnick, Frank C Tinsley, Brian J Eastwood, Todd M Suter, Charles H Mitch, Mark L Heiman

Am J Physiol Regul Integr Comp Physiol. 2003 Jun;284(6):R1399-408.

PMID: 12736177

Abstract:

Agonists to opioid receptors induce a positive energy balance, whereas antagonists at these receptors reduce food intake and body weight in rodent models of obesity. An analog of 3,4-dimethyl-4-(3-hydroxyphenyl)piperidine, LY255582, is a potent non-morphinan antagonist for mu-, kappa-, and delta-receptors (K(i) of 0.4, 2.0, and 5.2 nM, respectively). In the present study, we examined the effects of oral LY255582 treatment on caloric intake, calorie expenditure, and body composition in dietary-induced obese rats. Acute oral treatment of LY255582 produced a dose-dependent decrease in energy intake and respiratory quotient (RQ), which correlated with the occupancy of central opioid receptors. Animals receiving chronic oral treatment with LY255582 for 14 days maintained a negative energy balance that was sustained by increased lipid use. Analysis of body composition revealed a reduction in fat mass accretion, with no change in lean body mass, in animals treated with LY255582. Therefore, chronic treatment with LY255582 reduces adipose tissue mass by reducing energy intake and stimulating lipid use.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP119193098	LY255582		119193-09-8	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: