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PF-4708671 Activates AMPK Independently of p70S6K1 Inhibition

PF-4708671 Activates AMPK Independently of p70S6K1 Inhibition

Gilad W Vainer, Ann Saada, Juliane Kania-Almog, Adir Amartely, Jacob Bar-Tana, Rachel Hertz

PLoS One. 2014 Sep 9;9(9):e107364.

PMID: 25202971

Abstract:

The P70 ribosomal protein S6 kinase 1 (P70S6K1) is activated by the mammalian target of rapamycin (mTORC1) and regulates proliferation, growth, and metabolism. PF-4708671 is a novel, cell-permeable, has been proposed to be a highly specific inhibitor of p70S6K1. It is used in micromolar concentration range to dissect signaling pathways downstream of mTORC1 and to study the function of p70S6K1. Here we show that PF-4708671 induces AMP-activated protein kinase (AMPK) phosphorylation and activation in immortalized mouse embryonic fibroblasts (MEF) independently of p70S6K1, due to specific inhibition of mitochondrial respiratory chain Complex I.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1255517760	PF-4708671		1255517-76-0	Price

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