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Pharmacokinetics of Total Thyroxine in Dogs After Administration of an Oral Solution of Levothyroxine Sodium

Pharmacokinetics of Total Thyroxine in Dogs After Administration of an Oral Solution of Levothyroxine Sodium

G Le Traon, S Burgaud, L J I Horspool

J Vet Pharmacol Ther. 2008 Apr;31(2):95-101.

PMID: 18307500

Abstract:

Oral L-thyroxine (L-T4) supplementation is used to replace thyroid hormone concentrations in dogs with hypothyroidism. The pharmacokinetics of L-T4 following administration of a solution (Leventa) was investigated in healthy dogs. L-T4 was absorbed fairly rapidly (t(max) 3 h). A mean bioavailability of 22% was calculated following a single oral administration of 40 microg L-T4/kg body weight. Repeated oral administration at the same dose for 14 consecutive days did not lead to any accumulation of T4 in serum. After intravenous administration of L-T4, a serum half-life of 11.6 h was calculated. Food intake concomitant with L-T4 oral administration delayed L-T4 absorption and decreased its rate and extent by about 45%. The relative bioavailability of L-T4 following administration of a tablet formulation was about 50% of that of the L-T4 solution. The pharmacokinetic properties of liquid L-T4 after oral administration support the use of a dose rate of 20 microg/kg once daily, as a starting dose for replacement therapy in dogs with hypothyroidism.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP51489-A	L-Thyroxine (T4) solution		51-48-9	Price

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