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Phosphocalyculin C as a Pyrophosphate Protoxin of Calyculin C in the Marine Sponge Discodermia Calyx

Phosphocalyculin C as a Pyrophosphate Protoxin of Calyculin C in the Marine Sponge Discodermia Calyx

Yoko Egami, Toshiyuki Wakimoto, Ikuro Abe

Bioorg Med Chem Lett. 2014 Nov 15;24(22):5150-3.

PMID: 25442302

Abstract:

Calyculin C, a minor derivative of the calyculins, has an additional methyl group on C32 of calyculin A. A recent biosynthetic study of calyculins revealed that an end product of calyculin biosynthesis is the pyrophosphate form, phosphocalyculin A. However, the pyrophosphate counterpart derived from calyculin C had not been reported. We isolated phosphocalyculin C as a minor pyrophosphate derivative, by a detailed investigation of an extract from the sponge Discodermia calyx. The treatment of phosphocalyculin C with the D. calyx cell-free extract significantly enhanced its cytotoxicity, providing molecular evidence for its role as the protoxin of calyculin C.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP101932712	Calyculin A from Discodermia calyx		101932-71-2	Price

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