Home
Resources
Publications
Platelets Release CXCL4L1, a Nonallelic Variant of the Chemokine Platelet factor-4/CXCL4 and Potent Inhibitor of Angiogenesis

Platelets Release CXCL4L1, a Nonallelic Variant of the Chemokine Platelet factor-4/CXCL4 and Potent Inhibitor of Angiogenesis

Sofie Struyf, Marie D Burdick, Paul Proost, Jo Van Damme, Robert M Strieter

Circ Res. 2004 Oct 29;95(9):855-7.

PMID: 15459074

Abstract:

Platelet factor-4 (PF-4)/CXCL4 was the first chemokine described to inhibit neovascularization. Here, the product of the nonallelic variant gene of CXCL4, PF-4var1/PF-4alt, designated CXCL4L1, was isolated for the first time from thrombin-stimulated human platelets and purified to homogeneity. Although secreted CXCL4 and CXCL4L1 differ in only three amino acids, CXCL4L1 was more potent in inhibiting chemotaxis of human microvascular endothelial cells toward interleukin-8 (IL-8)/CXCL8 or basic fibroblast growth factor (bFGF). In vivo, CXCL4L1 was also more effective than CXCL4 in inhibiting bFGF-induced angiogenesis in rat corneas. Thus, activated platelets release CXCL4L1, a potent regulator of endothelial cell biology, which affects angiogenesis and vascular diseases.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413100	PF-4 (CXCL4) human			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: