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Poly-arginine-fused Calpastatin Peptide, a Living Cell Membrane-Permeable and Specific Inhibitor for Calpain

Poly-arginine-fused Calpastatin Peptide, a Living Cell Membrane-Permeable and Specific Inhibitor for Calpain

Hai-Yan Wu, Kazuhito Tomizawa, Masayuki Matsushita, Yun-Fei Lu, Sheng-Tian Li, Hideki Matsui

Neurosci Res. 2003 Sep;47(1):131-5.

PMID: 12941454

Abstract:

Calpain, a Ca2+-dependent neutral protease, is highly related to the pathogenesis of a variety of disorders and its inhibitors offer potential for therapeutic intervention. General calpain inhibitors, however, have the disadvantage of a lack of specificity or poor cellular permeability or oxidization under physiological conditions. Here, we developed a membrane-permeable specific calpain inhibitor by fusing calpastatin peptide (CS) and 11 poly-arginine peptides (11R). The 11R-fused CS (11R-CS) effectively penetrated across the plasma membrane of living neurons and significantly inhibited calpain activity in the cells.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42415262	Calpastatin Peptide			Price

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