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Prevention of Islet Allograft Rejection in Diabetic Mice by Targeting Janus Kinase 3 With 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (JANEX-1)

Marina Cetkovic-Cvrlje, Angela L Dragt, Fatih M Uckun

Arzneimittelforschung. 2003;53(9):648-54.

PMID: 14558439

Abstract:

Janus kinase (JAK) 3-deficient mice were not able to reject allogeneic islet allografts. The JAK3 inhibitor 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (CAS 202475-60-3, JANEX-1, WHI-P131) prevented the rejection of islet allografts in mice with a normal JAK3 expression status. The combination of JANEX-1 and cyclosporin A (CAS 59865-13-3) was more effective than either agent alone.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP202475603 JAK3 Inhibitor I - CAS 202475-60-3 JAK3 Inhibitor I - CAS 202475-60-3 202475-60-3 Price
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