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Profiling Small Molecule Inhibitors Against Helix-Receptor Interactions: The Bcl-2 Family Inhibitor BH3I-1 Potently Inhibits p53/hDM2

Jason R Porter, Mark R Helmers, Ping Wang, Jennifer L Furman, Stephen T Joy, Paramjit S Arora, Indraneel Ghosh

Chem Commun (Camb). 2010 Nov 14;46(42):8020-2.

PMID: 20856941

Abstract:

We validate a practical methodology for the rapid profiling of small molecule inhibitors of protein-protein interactions. We find that a well known BH3 family inhibitor can potently inhibit the p53/hDM2 interaction.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP300817689 BH3I-1 BH3I-1 300817-68-9 Price
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