Home
Resources
Publications
Protective Effect of Naringin on DSS-Induced Ulcerative Colitis in Mice

Protective Effect of Naringin on DSS-Induced Ulcerative Colitis in Mice

Hongyang Cao, Jiuxi Liu, Peng Shen, Jiapei Cai, Yuchang Han, Kunpeng Zhu, Yunhe Fu, Naisheng Zhang, Zecai Zhang, Yongguo Cao

J Agric Food Chem. 2018 Dec 19;66(50):13133-13140.

PMID: 30472831

Abstract:

Peroxisome proliferator-activated receptor γ (PPARγ) is an important member of the nuclear receptor superfamily. Previous studies have shown the satisfactory anti-inflammatory role of PPARγ in experimental colitis models, mainly through negatively regulating several transcription factors such as nuclear factor-κB (NF-κB). Therefore, regulating PPARγ and PPARγ-related pathways has great promise for treating ulcerative colitis (UC). In the present study, our objective was to explore the potential effect of naringin on dextran sulfate sodium (DSS) induced UC in mice and its involved potential mechanism. We found that naringin significantly relieved DSS-induced disease activities index (DAI), colon length shortening, and colonic pathological damage. Exploration of the potential mechanisms demonstrated that naringin significantly activated DSS-induced PPARγ and subsequently suppressed NF-κB activation. PPARγ inhibitor GW9662 largely abrogated the roles of naringin in vitro. Moreover, DSS induced the activation of mitogen-activated protein kinase (MAPK) and (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome was inhibited by naringin. Tight junction (TJ) architecture in naringin groups was also maintained by regulating zonula occludens-1 (ZO-1) expression. These results suggested that naringin may be a potential natural agent for protecting mice from DSS-induced UC.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP10236472-A	Naringin		10236-47-2	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: