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RK-682, a Potent Inhibitor of Tyrosine Phosphatase, Arrested the Mammalian Cell Cycle Progression at G1phase

T Hamaguchi, T Sudo, H Osada

FEBS Lett. 1995 Sep 18;372(1):54-8.

PMID: 7556642

Abstract:

A specific inhibitor of protein tyrosine phosphatase (PTPase), RK-682 (3-hexadecanoyl-5-hydroxymethyl-tetronic acid) was isolated from microbial metabolites. In vitro, RK-682 inhibited dephosphorylation activity of CD45 and VHR with IC50 54 and 2.0 microM, respectively. In situ, sodium orthovanadate and RK-682 enhanced the phosphotyrosine level of Ball-1 cells, a human B cell leukemia, but not the phosphoserine/threonine level. The PTPase inhibitors, however, had the different arrest point on the cell cycle progression. Sodium orthovanadate inhibited the cell cycle progression at G2/M boundary phase, on the other hand, RK-682 inhibited the G1/S transition.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP150627375 RK-682 RK-682 150627-37-5 Price
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