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Sensitive determination of bromhexine hydrochloride based on its quenching effect on luminol/H 2 O 2 electrochemiluminescence system

Sensitive determination of bromhexine hydrochloride based on its quenching effect on luminol/H 2 O 2 electrochemiluminescence system

Dexian Kong, Siqin Huang, Jiansong Cheng, Qizhao Zhuang, Yijun Liu, Chun-Hua Lu

Luminescence. 2018 Jun;33(4):698-703.

PMID: 29605968

Abstract:

In this paper, the electrochemiluminescence (ECL) behavior of luminol/H2 O2 system in the presence of bromhexine hydrochloride (BrH) was investigated. It was found that the ECL intensity of luminol/H2 O2 system on a platinum electrode could be intensely quenched by BrH owing to the scavenging superoxide radical ability of BrH, and therefore the sensitive determination of BrH was possible. Under optimal conditions, the quenched ECL intensity was linear to the concentration of BrH in a wide range of 0.08 to 500 μM, with a detection limit of 0.02 μM (signal-to-noise ratio (S/N) = 3). This ECL method possessed the merits of rapid, simple and sensitive, and was successfully applied to the BrH quantification in pharmaceutical preparations with satisfactory recoveries of 91.0 ± 4.0 to 106.5 ± 3.4%. The possible route of the quenched ECL of luminol/H2 O2 in the presence of BrH was also discussed.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP521313	Luminol		521-31-3	Price

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