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Sister-chromatid Exchanges, Chromosomal Aberrations and Cytotoxicity Produced by Topoisomerase II-targeted Drugs in Sensitive (A2780) and Resistant (A2780-DX3) Human Ovarian Cancer Cells: Correlations With the Formation of DNA Double-Strand Breaks

Sister-chromatid Exchanges, Chromosomal Aberrations and Cytotoxicity Produced by Topoisomerase II-targeted Drugs in Sensitive (A2780) and Resistant (A2780-DX3) Human Ovarian Cancer Cells: Correlations With the Formation of DNA Double-Strand Breaks

E Noviello, M G Aluigi, G Cimoli, E Rovini, A Mazzoni, S Parodi, F De Sessa, P Russo

Mutat Res. 1994 Nov 1;311(1):21-9.

PMID: 7526171

Abstract:

Doxorubicin, ellipticine and etoposide are antineoplastic drugs with topoisomerase II inhibitory activity. The relationship between drug-induced sister-chromatid exchanges (SCEs) or chromosomal aberrations (CAs) and cytotoxicity, or drug-induced DNA double-strand breaks (DSBs) and cytotoxicity, or drug-induced SCEs and DSBs was investigated in human ovarian cancer cells sensitive (A2780) and resistant (A2780-DX3) to topoisomerase II inhibitors. 30-min drug treatments produced SCEs, CAs and DSBs in sensitive cells, doxorubicin being more potent than etoposide at equimolar concentrations. The same treatments of resistant (A2780-DX3) cells did not produce chromosomal damage (SCEs, CAs, DSBs) and no cytotoxicity was observed. A plot of cytotoxicity versus SCEs indicated a good correlation between these two parameters for topoisomerase II inhibitors and not for mytomicin C. The plot of DSBs versus SCEs also showed a very good correlation.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP519233	Ellipticine - CAS 519-23-3		519-23-3	Price

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