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Spermidine: A Physiological Autophagy Inducer Acting as an Anti-Aging Vitamin in Humans?

Frank Madeo, Maria A Bauer, Didac Carmona-Gutierrez, Guido Kroemer

Autophagy. 2019 Jan;15(1):165-168.

PMID: 30306826

Abstract:

Spermidine is a natural polyamine that stimulates cytoprotective macroautophagy/autophagy. External supplementation of spermidine extends lifespan and health span across species, including in yeast, nematodes, flies and mice. In humans, spermidine levels decline with aging, and a possible connection between reduced endogenous spermidine concentrations and age-related deterioration has been suggested. Recent epidemiological data support this notion, showing that an increased uptake of this polyamine with spermidine-rich food diminishes overall mortality associated with cardiovascular diseases and cancer. Here, we discuss nutritional and other possible routes to counteract the age-mediated decline of spermidine levels.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP124209 Spermidine Spermidine 124-20-9 Price
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