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Structure-activity Relationship Analysis of a Novel Necroptosis Inhibitor, Necrostatin-5

Ke Wang, Jinfeng Li, Alexei Degterev, Emily Hsu, Junying Yuan, Chengye Yuan

Bioorg Med Chem Lett. 2007 Mar 1;17(5):1455-65.

PMID: 17270434

Abstract:

Necrostatin-5 (Nec-5) is a novel potent small-molecule inhibitor of necroptosis structurally distinct from previously described Necrostatin-1 (Nec-1), and therefore, represents a new direction for the inhibition of this cellular caspase-independent necrotic cell death mechanism. Here, we describe a series of structural modifications of Nec-5 and the structure-activity relationship (SAR) of Nec-5 series in inhibiting necroptosis.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP337349549 Necrostatin-5 Necrostatin-5 337349-54-9 Price
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