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Structure-activity Relationship and Synthetic Methodologies of α-santonin Derivatives With Diverse Bioactivities: A Mini-Review

Structure-activity Relationship and Synthetic Methodologies of α-santonin Derivatives With Diverse Bioactivities: A Mini-Review

Jiangming Wang, Siyuan Su, Shangzhe Zhang, Shiyang Zhai, Ruilong Sheng, Wenhui Wu, Ruihua Guo

Eur J Med Chem. 2019 Aug 1;175:215-233.

PMID: 31082765

Abstract:

α-Santonin, a sesquiterpene lactone isolated from Artemisia Santonica, possesses diverse bioactivities including antioxidant, anti-inflammation, immunosuppressive, anti-roundworm, anti-malaria, etc. However, its bioactivities are not satisfactory and need to be further optimized. Thus, many α-santonin derivatives were synthesized on the basis of rings A, B and C for the discovery of new analogues with prominent bioactivities. Herein, we reviewed and discussed the related synthetic methodologies, diverse bioactivities and structure-activity relationships (SAR) of α-santonin derivatives.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP481061	α-Santonin		481-06-1	Price

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