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Structure-activity Relationship Study of a Novel Necroptosis Inhibitor, necrostatin-7

Weihong Zheng, Alexei Degterev, Emily Hsu, Junying Yuan, Chengye Yuan

Bioorg Med Chem Lett. 2008 Sep 15;18(18):4932-5.

PMID: 18768316

Abstract:

Necroptosis is a regulated caspase-independent cell death mechanism characterized by morphological features resembling non-regulated necrosis. Necrotatin-7 (Nec-7), a novel potent small-molecule inhibitor of necroptosis, is structurally distinct from previously described necrostatins (Nec-1, Nec-3, Nec-4 and Nec-5). Here, we describe a series of structural modifications and the structure-activity relationship (SAR) of the Nec-7 series for inhibiting necroptosis.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP351062083 Necrostatin-7 Necrostatin-7 351062-08-3 Price
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