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Study of Cardioprotective Effects of Necroptosis Inhibitors on Isolated Rat Heart Subjected to Global Ischemia-Reperfusion

Yu V Dmitriev, S M Minasian, E A Demchenko, M M Galagudza

Bull Exp Biol Med. 2013 Jun;155(2):245-8.

PMID: 24131001

Abstract:

The cardioprotective effects of necroptosis inhibitors necrostatin-1 and necrostatin-5 were studied on the isolated heart model in rats. Intraperitoneal injection of necrostatin-1 (1.65 mg/kg) or necrostatin-5 (2.46 mg/kg) 60 min before reperfusion of the isolated heart reduced the infarction zone caused by 30-min global ischemia and 120-min reperfusion. Intracoronary injection of necrostatin-1 (44.5 μmol/liter) caused an increase of left-ventricular systolic pressure, that is produced a positive inotropic effect, but did not reduce the infarction zone.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP337349549 Necrostatin-5 Necrostatin-5 337349-54-9 Price
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