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Synthesis and Activity of 1-N-iminosugar Inhibitors, Siastatin B Analogues for alpha-N-acetylgalactosaminidase and beta-N-acetylglucosaminidase

Y Nishimura, T Satoh, T Kudo, S Kondo, T Takeuchi

Bioorg Med Chem. 1996 Jan;4(1):91-6.

PMID: 8689244

Abstract:

N-Acetylgalactosamine-based 1-N-iminosugars, new types of glycosidase inhibitor have been synthesized by modeling on siastatin B, isolated from a Streptomyces culture. The analogues of siastatin B were proved to be potent inhibitors for alpha-N-acetylgalactosaminidase and/or beta-N-acetylglucosaminidase.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP54795583 Siastatin B Siastatin B 54795-58-3 Price
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